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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
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《医学前沿(英文)》 2013年 第7卷 第1期 页码 25-30 doi: 10.1007/s11684-013-0244-8
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.
关键词: FGF21 metabolism pharmacology physiology clinical relevance
Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus
Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO
《医学前沿(英文)》 2009年 第3卷 第2期 页码 158-163 doi: 10.1007/s11684-009-0042-5
关键词: tetracycline regulatory system adeno-associated virus basic fibroblast growth factor gene regulation
FGF23 associated bone diseases
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《医学前沿(英文)》 2013年 第7卷 第1期 页码 65-80 doi: 10.1007/s11684-013-0254-6
Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease.
关键词: fibroblast growth factor 23 FGF receptor phosphate metabolism Klotho bone disease
Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113
Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 357-362 doi: 10.1007/s11684-009-0046-1
关键词: carcinoma squamous cell pituitary tumor transforming gene (PTTG) protein basic fibroblast growth factor
Economic Growth Model Based on Six Basic Factors of Production—Xu Growth Rate Equation
Shou-bo Xu,Zong-yuan Huang
《工程管理前沿(英文)》 2014年 第1卷 第2期 页码 160-175 doi: 10.15302/J-FEM-2014024
关键词: six basic factors of production economic growth model Xu Growth Rate Equation
Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li
《医学前沿(英文)》 2020年 第14卷 第3期 页码 262-272 doi: 10.1007/s11684-019-0717-5
Expression of PC-cell-derived growth factor in breast cancer
Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 426-430 doi: 10.1007/s11684-009-0085-7
关键词: PC-cell-derived growth factor breast neoplasms clinical markers
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 447-451 doi: 10.1007/s11684-009-0082-x
关键词: cervical cancer lymphatic vessel density blood vessel density platelet-derived growth factor
GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong
《医学前沿(英文)》 2007年 第1卷 第3期 页码 248-252 doi: 10.1007/s11684-007-0047-x
关键词: control stimulation mitogen-activated growth factor process
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 177-180 doi: 10.1007/s11684-009-0021-x
关键词: vascular endothelial growth factors restenosis reactive oxygen species endothelial cells vascular smooth muscle cell
An investigation on prevalent strategies for XFEM-based numerical modeling of crack growth in porous
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 914-936 doi: 10.1007/s11709-021-0750-8
关键词: numerical modeling extended finite element method porous media crack growth stress intensity factor
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 284-286 doi: 10.1007/s11684-009-0062-1
关键词: vascular endothelial growth factor nitric oxide N-nitro-L-arginine methyl ester vascular endothelial cells
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《医学前沿(英文)》 2014年 第8卷 第4期 页码 445-455 doi: 10.1007/s11684-014-0378-3
Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis. We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC). Oral sildenafil, a PDE5 inhibitor, was administered in the therapy group. In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiac fibroblast activation (proliferation and transformation to myofibroblasts). Sildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac fibroblast activation but did not block TAC-induced transforming growth factor-β1 (TGF-β1) production and phosphorylation of Smad2/3. In isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformation, proliferation and collagen synthesis. Furthermore, we found that sildenafil induced phosphorylated cAMP response element binding protein (CREB) and reduced CREB-binding protein 1 (CBP1) recruitment to Smad transcriptional complexes. PDE5 inhibition prevents cardiac fibrosis by reducing CBP1 recruitment to Smad transcriptional complexes through CREB activation in cardiac fibroblasts.
关键词: PDE5 cardiac fibrosis TGF-β CREB
Wenjie Zhu, Binghe Xu
《医学前沿(英文)》 2021年 第15卷 第2期 页码 208-220 doi: 10.1007/s11684-020-0795-4
关键词: endocrine-resistant HR+/HER2- advanced breast cancer randomized clinical trials meta-analysis targeted therapy
徐永江,臧 坤,柳学周,史 宝,陈圣毅
《中国工程科学》 2015年 第17卷 第1期 页码 67-73
为了在蛋白水平认识星突江鲽(Platichthys stellatus)胰岛素样生长因子I(IGF-I)的生长调控作用及机制,采用RT-PCR方法扩增了其成熟肽片段,利用原核表达载体pET-28a成功构建了重组星突江鲽IGF-I/pET-28a质粒,转化至大肠杆菌BL21(DE3)后经IPTG诱导获得了N端含6个组氨酸的重组星突江鲽IGF-I蛋白。获得的重组IGF-I蛋白大小为12.1 kD,37 ℃下用0.5 mmol/L的异丙基-β-D-硫代半乳糖苷(IPTG)诱导3 h时目的蛋白表达量最高,占菌体总蛋白的39.8 %,主要以包涵体形式存在。Western blotting免疫印迹表明星突江鲽IGF-I重组蛋白均可被6×His抗体特异性识别。包涵体经6 mol/L盐酸胍变性、Ni2+离子亲和柱纯化和尿素梯度复性后,可获得高纯度的IGF-I重组蛋白。细胞增殖试验结果显示0.6 μg/mL 的星突江鲽IGF-I重组蛋白能显著促进人胚胎肾细胞HEK293T的增殖而大于1.8 μg/mL时则表现出抑制作用。本研究成功构建了星突江鲽IGF-I体外高效表达系统,并获得具有细胞水平生物活性的星突江鲽IGF-I重组蛋白,结果可为深入探究IGF-I在星突江鲽生长发育中的作用机制及研制高效绿色的促生长制剂提供基础资料。
标题 作者 时间 类型 操作
Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus
Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO
期刊论文
Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113
Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,
期刊论文
Economic Growth Model Based on Six Basic Factors of Production—Xu Growth Rate Equation
Shou-bo Xu,Zong-yuan Huang
期刊论文
Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblastgrowth factors
Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li
期刊论文
Expression of PC-cell-derived growth factor in breast cancer
Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,
期刊论文
The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
期刊论文
Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor
GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong
期刊论文
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
期刊论文
An investigation on prevalent strategies for XFEM-based numerical modeling of crack growth in porous
期刊论文
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
期刊论文
monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growthfactor β-induced Smad signaling
null
期刊论文
Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor
Wenjie Zhu, Binghe Xu
期刊论文